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New Conductometric Titration Methods for Determination of Diphenhydramine Hydrochloride Using Sodium Tetraphenylborate and Cetylpyridinium Bromide

Received: 15 January 2018     Accepted: 31 January 2018     Published: 26 February 2018
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Abstract

Sodium tetraphenylborate (TPB) and cetylpyridinium bromide (CPB) were used as titrant for the conductometric determination of diphenhydramine hydrochloride (DPH) drug through ion association complex formation and then the conductance of the solution is measured as a function of the volume of titrant. The effect of the solvent, reagent concentration, temperature and molar combining ratio of the formed ion-associates were studied and evaluated. The suggested method was applied for the determination of diphenhydramine hydrochloride in pure form and pharmaceutical preparations. The described procedures allowed the determination of the studied drug in bi-distilled water in the range of 0.75–16 mg. Statistical treatment of the experimental results indicates that the method is precise and accurate. The accuracy of the method was indicated by excellent recovery and the precision supported by the low relative standard deviation <1%. The sensitivity of the proposed method was discussed and the results were compared with the potentiometric pharmacopoeial method. The proposed procedure was simple, precise and low cost and can be applied for the routine measurements of the cited drug.

Published in International Journal of Pharmacy and Chemistry (Volume 4, Issue 1)
DOI 10.11648/j.ijpc.20180401.12
Page(s) 8-15
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Diphenhydramine Hydrochloride, Sodium Tetraphenylborate, Cetylpyridinium Bromide, Conductometry, Pharmaceutical Formulations

References
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    Safwan Ashour, Haitham Aboudan. (2018). New Conductometric Titration Methods for Determination of Diphenhydramine Hydrochloride Using Sodium Tetraphenylborate and Cetylpyridinium Bromide. International Journal of Pharmacy and Chemistry, 4(1), 8-15. https://doi.org/10.11648/j.ijpc.20180401.12

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    ACS Style

    Safwan Ashour; Haitham Aboudan. New Conductometric Titration Methods for Determination of Diphenhydramine Hydrochloride Using Sodium Tetraphenylborate and Cetylpyridinium Bromide. Int. J. Pharm. Chem. 2018, 4(1), 8-15. doi: 10.11648/j.ijpc.20180401.12

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    AMA Style

    Safwan Ashour, Haitham Aboudan. New Conductometric Titration Methods for Determination of Diphenhydramine Hydrochloride Using Sodium Tetraphenylborate and Cetylpyridinium Bromide. Int J Pharm Chem. 2018;4(1):8-15. doi: 10.11648/j.ijpc.20180401.12

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  • @article{10.11648/j.ijpc.20180401.12,
      author = {Safwan Ashour and Haitham Aboudan},
      title = {New Conductometric Titration Methods for Determination of Diphenhydramine Hydrochloride Using Sodium Tetraphenylborate and Cetylpyridinium Bromide},
      journal = {International Journal of Pharmacy and Chemistry},
      volume = {4},
      number = {1},
      pages = {8-15},
      doi = {10.11648/j.ijpc.20180401.12},
      url = {https://doi.org/10.11648/j.ijpc.20180401.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20180401.12},
      abstract = {Sodium tetraphenylborate (TPB) and cetylpyridinium bromide (CPB) were used as titrant for the conductometric determination of diphenhydramine hydrochloride (DPH) drug through ion association complex formation and then the conductance of the solution is measured as a function of the volume of titrant. The effect of the solvent, reagent concentration, temperature and molar combining ratio of the formed ion-associates were studied and evaluated. The suggested method was applied for the determination of diphenhydramine hydrochloride in pure form and pharmaceutical preparations. The described procedures allowed the determination of the studied drug in bi-distilled water in the range of 0.75–16 mg. Statistical treatment of the experimental results indicates that the method is precise and accurate. The accuracy of the method was indicated by excellent recovery and the precision supported by the low relative standard deviation <1%. The sensitivity of the proposed method was discussed and the results were compared with the potentiometric pharmacopoeial method. The proposed procedure was simple, precise and low cost and can be applied for the routine measurements of the cited drug.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - New Conductometric Titration Methods for Determination of Diphenhydramine Hydrochloride Using Sodium Tetraphenylborate and Cetylpyridinium Bromide
    AU  - Safwan Ashour
    AU  - Haitham Aboudan
    Y1  - 2018/02/26
    PY  - 2018
    N1  - https://doi.org/10.11648/j.ijpc.20180401.12
    DO  - 10.11648/j.ijpc.20180401.12
    T2  - International Journal of Pharmacy and Chemistry
    JF  - International Journal of Pharmacy and Chemistry
    JO  - International Journal of Pharmacy and Chemistry
    SP  - 8
    EP  - 15
    PB  - Science Publishing Group
    SN  - 2575-5749
    UR  - https://doi.org/10.11648/j.ijpc.20180401.12
    AB  - Sodium tetraphenylborate (TPB) and cetylpyridinium bromide (CPB) were used as titrant for the conductometric determination of diphenhydramine hydrochloride (DPH) drug through ion association complex formation and then the conductance of the solution is measured as a function of the volume of titrant. The effect of the solvent, reagent concentration, temperature and molar combining ratio of the formed ion-associates were studied and evaluated. The suggested method was applied for the determination of diphenhydramine hydrochloride in pure form and pharmaceutical preparations. The described procedures allowed the determination of the studied drug in bi-distilled water in the range of 0.75–16 mg. Statistical treatment of the experimental results indicates that the method is precise and accurate. The accuracy of the method was indicated by excellent recovery and the precision supported by the low relative standard deviation <1%. The sensitivity of the proposed method was discussed and the results were compared with the potentiometric pharmacopoeial method. The proposed procedure was simple, precise and low cost and can be applied for the routine measurements of the cited drug.
    VL  - 4
    IS  - 1
    ER  - 

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Author Information
  • Analytical Chemistry Laboratory, Department of Chemistry, Faculty of Sciences, University of Aleppo, Aleppo, Syria

  • Analytical Chemistry Laboratory, Department of Chemistry, Faculty of Sciences, University of Aleppo, Aleppo, Syria

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