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Study on Dissociation Equilibria of Eberconazole Nitrate in Micellar Media by Spectrophotometry

Received: 15 August 2019     Accepted: 9 September 2019     Published: 11 October 2019
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Abstract

The equilibrium dissociation constant (KD) is the basic parameter to evaluate the binding property of the chemical structure of compounds. Thus, a variety of analytical methods have been established to determine the KD values, including radioligand binding assay, surface plasmon resonance method, fluorescence energy resonance transfer method, affinity chromatography, and isothermal titration calorimetry. Here we present a detailed overview of the dissociation equilibria of Eberconazole nitrate (EBZ) in homogeneous and heterogeneous systems, focusing primarily on methods that are based on spectrophotometrically of the dissociation reaction. The Dissociation equilibria of Eberconazole nitrate (EBZ) in homogeneous and heterogeneous systems were studied spectrophotometrically in Britton-Robinson’s (BR) buffer at 25°C. Acidity constant of EBZ in BR buffer was found to be 9.5. The effect of anionic, cationic and non-ionic surfactants applied in the concentration exceeding critical micellar concentration (cmc) on acid – base properties of EBZ were also examined. The results revealed a shift of pKa values in micellar media comparing to the values obtained in BR buffer. These shifts in pKa values are more in cationic and anionic micellar media compared with that of non-ionic. The observed differences in pKa values between micellar media and BR buffer solution ranged between -6.0 to -2.0 units. The micellar-mediated pKa shifts can be attributed to the differences between the mean intrinsic solvent properties of the interfacial and bulk phases, with an additional contribution from the electrostatic micellar surface potential in the case of the charged aqueous micellar solutions.

Published in International Journal of Pharmacy and Chemistry (Volume 5, Issue 5)
DOI 10.11648/j.ijpc.20190505.11
Page(s) 48-51
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Dissociation Equilibria, Eberconazole Nitrate, Micellar Media, Spectrophotometry

References
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Cite This Article
  • APA Style

    Marothu Vamsi Krishna, Salah Ali Mahgoub Idris, G. Madhavi, B. Jalachandra Reddy, M. Sowhardhra, et al. (2019). Study on Dissociation Equilibria of Eberconazole Nitrate in Micellar Media by Spectrophotometry. International Journal of Pharmacy and Chemistry, 5(5), 48-51. https://doi.org/10.11648/j.ijpc.20190505.11

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    ACS Style

    Marothu Vamsi Krishna; Salah Ali Mahgoub Idris; G. Madhavi; B. Jalachandra Reddy; M. Sowhardhra, et al. Study on Dissociation Equilibria of Eberconazole Nitrate in Micellar Media by Spectrophotometry. Int. J. Pharm. Chem. 2019, 5(5), 48-51. doi: 10.11648/j.ijpc.20190505.11

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    AMA Style

    Marothu Vamsi Krishna, Salah Ali Mahgoub Idris, G. Madhavi, B. Jalachandra Reddy, M. Sowhardhra, et al. Study on Dissociation Equilibria of Eberconazole Nitrate in Micellar Media by Spectrophotometry. Int J Pharm Chem. 2019;5(5):48-51. doi: 10.11648/j.ijpc.20190505.11

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  • @article{10.11648/j.ijpc.20190505.11,
      author = {Marothu Vamsi Krishna and Salah Ali Mahgoub Idris and G. Madhavi and B. Jalachandra Reddy and M. Sowhardhra and D. Gowri Sankar},
      title = {Study on Dissociation Equilibria of Eberconazole Nitrate in Micellar Media by Spectrophotometry},
      journal = {International Journal of Pharmacy and Chemistry},
      volume = {5},
      number = {5},
      pages = {48-51},
      doi = {10.11648/j.ijpc.20190505.11},
      url = {https://doi.org/10.11648/j.ijpc.20190505.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20190505.11},
      abstract = {The equilibrium dissociation constant (KD) is the basic parameter to evaluate the binding property of the chemical structure of compounds. Thus, a variety of analytical methods have been established to determine the KD values, including radioligand binding assay, surface plasmon resonance method, fluorescence energy resonance transfer method, affinity chromatography, and isothermal titration calorimetry. Here we present a detailed overview of the dissociation equilibria of Eberconazole nitrate (EBZ) in homogeneous and heterogeneous systems, focusing primarily on methods that are based on spectrophotometrically of the dissociation reaction. The Dissociation equilibria of Eberconazole nitrate (EBZ) in homogeneous and heterogeneous systems were studied spectrophotometrically in Britton-Robinson’s (BR) buffer at 25°C. Acidity constant of EBZ in BR buffer was found to be 9.5. The effect of anionic, cationic and non-ionic surfactants applied in the concentration exceeding critical micellar concentration (cmc) on acid – base properties of EBZ were also examined. The results revealed a shift of pKa values in micellar media comparing to the values obtained in BR buffer. These shifts in pKa values are more in cationic and anionic micellar media compared with that of non-ionic. The observed differences in pKa values between micellar media and BR buffer solution ranged between -6.0 to -2.0 units. The micellar-mediated pKa shifts can be attributed to the differences between the mean intrinsic solvent properties of the interfacial and bulk phases, with an additional contribution from the electrostatic micellar surface potential in the case of the charged aqueous micellar solutions.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Study on Dissociation Equilibria of Eberconazole Nitrate in Micellar Media by Spectrophotometry
    AU  - Marothu Vamsi Krishna
    AU  - Salah Ali Mahgoub Idris
    AU  - G. Madhavi
    AU  - B. Jalachandra Reddy
    AU  - M. Sowhardhra
    AU  - D. Gowri Sankar
    Y1  - 2019/10/11
    PY  - 2019
    N1  - https://doi.org/10.11648/j.ijpc.20190505.11
    DO  - 10.11648/j.ijpc.20190505.11
    T2  - International Journal of Pharmacy and Chemistry
    JF  - International Journal of Pharmacy and Chemistry
    JO  - International Journal of Pharmacy and Chemistry
    SP  - 48
    EP  - 51
    PB  - Science Publishing Group
    SN  - 2575-5749
    UR  - https://doi.org/10.11648/j.ijpc.20190505.11
    AB  - The equilibrium dissociation constant (KD) is the basic parameter to evaluate the binding property of the chemical structure of compounds. Thus, a variety of analytical methods have been established to determine the KD values, including radioligand binding assay, surface plasmon resonance method, fluorescence energy resonance transfer method, affinity chromatography, and isothermal titration calorimetry. Here we present a detailed overview of the dissociation equilibria of Eberconazole nitrate (EBZ) in homogeneous and heterogeneous systems, focusing primarily on methods that are based on spectrophotometrically of the dissociation reaction. The Dissociation equilibria of Eberconazole nitrate (EBZ) in homogeneous and heterogeneous systems were studied spectrophotometrically in Britton-Robinson’s (BR) buffer at 25°C. Acidity constant of EBZ in BR buffer was found to be 9.5. The effect of anionic, cationic and non-ionic surfactants applied in the concentration exceeding critical micellar concentration (cmc) on acid – base properties of EBZ were also examined. The results revealed a shift of pKa values in micellar media comparing to the values obtained in BR buffer. These shifts in pKa values are more in cationic and anionic micellar media compared with that of non-ionic. The observed differences in pKa values between micellar media and BR buffer solution ranged between -6.0 to -2.0 units. The micellar-mediated pKa shifts can be attributed to the differences between the mean intrinsic solvent properties of the interfacial and bulk phases, with an additional contribution from the electrostatic micellar surface potential in the case of the charged aqueous micellar solutions.
    VL  - 5
    IS  - 5
    ER  - 

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Author Information
  • Alliance Institute of Advanced Pharmaceutical and Health Sciences, Hyderabad, India

  • Chemistry Department, Faculty of Science, Tobruk University, Tobruk, Libya

  • Alliance Institute of Advanced Pharmaceutical and Health Sciences, Hyderabad, India

  • Alliance Institute of Advanced Pharmaceutical and Health Sciences, Hyderabad, India

  • Alliance Institute of Advanced Pharmaceutical and Health Sciences, Hyderabad, India

  • University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, India

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