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Augmentation Potency of Ethanol Seed Extract of Ricinodendron heudelotii on Some Male Reproductive Hormones in Wistar Albino Rats

Received: 27 April 2020     Accepted: 20 May 2020     Published: 9 June 2020
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Abstract

The quest for the use of plants in the management of reproductive hormone dysfunction prompted this research. This study explored the effects of Ricinodendron heudelotti seed ethanol extract on some male reproductive hormones. Twenty five male albino rats were used. The animals were grouped into five and each group had five (5) albino rats. The extract was processed from the seeds of Ricinodendron heudelotti. Group A served as control, group B animals were administered with 300mg/kg.bw, while groups C, D and E animals were administered 450, 600 and 750 mg/kg.bw of the extract respectively for twenty one days. The animals were sacrificed and their blood samples were collected for the assay of testosterone, Follicle stimulating hormone (FSH) and Luteinizing hormone (LH). From the results obtained, the serum testosterone level of the experimental animals showed a concentration dependent increase in all the extract administered groups when compared with the value of the control group. FSH and LH levels showed an increase statistically (p≤0.05) in comparison to the level of the control. Ricinodendron heudelotti seed extract effectively increased the reproductive hormones of the animals by increasing the serum Testosterone, FSH and LH levels, hence suggests its effectiveness in enhancement of the male reproductive function.

Published in International Journal of Pharmacy and Chemistry (Volume 6, Issue 2)
DOI 10.11648/j.ijpc.20200602.11
Page(s) 11-15
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Ricinodendron heudelotii, Testosterone, Follicle Stimulating Hormone, Luteinizing Hormone

References
[1] Lai, P. K, and Roy J. 2004. Antimicrobial and chemopreventive properties of herbs and spices. Curr medi chem. 1, (ii): 1351-60.
[2] Edeoga, H. O., Okwu, D. E. and Mbaebie, B. O. 2005. Phytochemical constituents of some Nigeria medicinal plants. African Journal of Biotechnology. 4: 685-688.
[3] Yakubu, M. T., Akanji, M. A. and Oladiji, A. T. 2005. Aphrodisiac potentials of the aqueous extract of Fadogiaagrestis (Schweinf. ExHiern) stem in male albino rats. Asian J Androl. 7: 399-404.
[4] Okwu, D. E. and Josiah, C. 2006. Evaluation of chemical compositions of two Nigerian Medicinal plants. Africa journal of Biotechnology 5 (4); 357-361.
[5] Odinga, T., Worlu-Wodu, Q. E. and Deekae, S. 2016. Bioprospective Screening of Ricinodendron heudelotii Seeds. J Anal Pharm Res 3 (7): 00084. DOI: 10.15406/japlr.2016.03.00084.
[6] Odinga, T. and Nwaokezi, C. O. 2020. Effect of Ricinodendron heudelotii seed extract on the oxidative stress biomarkers of Diabetic albino rats. Journal of Pharmaceutical Research and Reviews; 4: 19; 1-6.
[7] Browning, R., Schrick, F. N., Thompson, F. W. and Wakefield, T. 1998. Reproductive hormonal responses to ergotamine and ergonovine in cows during the luteal phase of the estrous cycle. Journal of Animal Sciences. 76: 1448-1454.
[8] Bratoeff, E., Cabeza, M., Ramirez, E., Heuze, Y. and Flores, E. 2005. Recent advances in the chemistry and pharmacological activity of new steroidal antiandrogens and 5 alpha-reductase inhibitors. Current Medicinal Chemistry. 12 (8): 927–43.
[9] Seftel, A. D., Mark, R. J, Secrest, A. R. and Smith, T. M. 2004. Restorative increases in serum testosterone levels are significantly correlated to improvement in sexual functioning. J Androl, 25 (9): 63-72.
[10] http://www.WebMD.com/sex-relationship/guide/male-reprductive-system.
[11] Storelu, S. G., Ennaji, A., Cocernot, A., and Spira, A. 1993. LH pulsatile Secretion and Testosterone blood levels influenced by sexual arousal in human males. Psychoneuroendocrinology 18 (3). 205-218.
[12] National Institute of Health, NIH. 2002. Animals in Research", public health service policy on Human Care and Use of Laboratory Animals, Health Research Extension Act of 1985, Public Law 99-158, reprinted 2002.
[13] Zade, V. S., Dabhadkar, D. K., Thakare, V. G. and Pare, S. R. 2013. Effect of aqueous extract of Moringa oleifera seed on sexual activity of male albino rats. Bio Forum-An Intern J. 5: 129-140.
[14] Zhana, P. and Ginka, A. 2015. Proximate composition of seeds and seed oil of melon (Cucumis melo. L).. Journal of cogent food and Agriculture, 1 (1); 001-005.
[15] Nzali, H. E., Tchiegang, C., Sandjon, B. and Meurens, M. 2016. Comparism of some phytochemical properties of oil extracted from Ricinodendron heudelotii (Bail) kernel by UV spectrophotometer. International journal of Bioscience. 8 (6), 93-102.
[16] Hammiehe, F. 2011. Preconception omega 3- Polyunsaturated fatty acid. Journal of lipid Research 38: 505-515.
[17] Uzoekwe, N. M. and Akens, H, A. 2016. Phytochemicals and nutritional characteristics of ethanol extract of the leaf and bark of Njangsa (Ricinodendron heudelotii) plant. Journal of applied science and environmental management. 20 (3); 522-527.
[18] Ezekwe, M. O., Besong, S. A. and Johnson, R. 2014. Nutritive composition of omega-3-fatty acids rich Ricinodendron heudelotii and its potential for nutrition. International journal of nutrition and metabolism. 6 (6), 56-62.
[19] Jones, M., Mark, P. and Waddel B. 2013. Maternal dietary omega-3- fatty acids and placenta function research. Journal of pharmaceutical Science, 18 (4), 7678.
[20] Odinga, T., Akaninwor, J. O. and Uselu, D. 2020b. Antihyperlipidemic potency of the seed extract of Ricinodendron heudelotii in wistar albino rats. Asian journal of biological sciences-Science alert- IN PRESS.
[21] Dieps, K. 2017. How do HDL and LDL differ structurally and functionally? Livestrong.com.
[22] Murphy, S. L., Xu, J. Q. and KD, K. D. 2012. Preliminary data for 2010. National vital statistics reports, Table B. Hyattsville, MD: National Center for Health Statistics.
[23] Lee, E. R., Kang, G. H. and Cho, S. H. 2007. Effects of Flavonoids on Human Health. Recent Pat. Biotechnology. 1 (2), 135-150.
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    Tamuno-boma Odinga, Ndidi Nwachoko, Christine Umanu Gabriel-Brisibe. (2020). Augmentation Potency of Ethanol Seed Extract of Ricinodendron heudelotii on Some Male Reproductive Hormones in Wistar Albino Rats. International Journal of Pharmacy and Chemistry, 6(2), 11-15. https://doi.org/10.11648/j.ijpc.20200602.11

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    ACS Style

    Tamuno-boma Odinga; Ndidi Nwachoko; Christine Umanu Gabriel-Brisibe. Augmentation Potency of Ethanol Seed Extract of Ricinodendron heudelotii on Some Male Reproductive Hormones in Wistar Albino Rats. Int. J. Pharm. Chem. 2020, 6(2), 11-15. doi: 10.11648/j.ijpc.20200602.11

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    AMA Style

    Tamuno-boma Odinga, Ndidi Nwachoko, Christine Umanu Gabriel-Brisibe. Augmentation Potency of Ethanol Seed Extract of Ricinodendron heudelotii on Some Male Reproductive Hormones in Wistar Albino Rats. Int J Pharm Chem. 2020;6(2):11-15. doi: 10.11648/j.ijpc.20200602.11

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  • @article{10.11648/j.ijpc.20200602.11,
      author = {Tamuno-boma Odinga and Ndidi Nwachoko and Christine Umanu Gabriel-Brisibe},
      title = {Augmentation Potency of Ethanol Seed Extract of Ricinodendron heudelotii on Some Male Reproductive Hormones in Wistar Albino Rats},
      journal = {International Journal of Pharmacy and Chemistry},
      volume = {6},
      number = {2},
      pages = {11-15},
      doi = {10.11648/j.ijpc.20200602.11},
      url = {https://doi.org/10.11648/j.ijpc.20200602.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20200602.11},
      abstract = {The quest for the use of plants in the management of reproductive hormone dysfunction prompted this research. This study explored the effects of Ricinodendron heudelotti seed ethanol extract on some male reproductive hormones. Twenty five male albino rats were used. The animals were grouped into five and each group had five (5) albino rats. The extract was processed from the seeds of Ricinodendron heudelotti. Group A served as control, group B animals were administered with 300mg/kg.bw, while groups C, D and E animals were administered 450, 600 and 750 mg/kg.bw of the extract respectively for twenty one days. The animals were sacrificed and their blood samples were collected for the assay of testosterone, Follicle stimulating hormone (FSH) and Luteinizing hormone (LH). From the results obtained, the serum testosterone level of the experimental animals showed a concentration dependent increase in all the extract administered groups when compared with the value of the control group. FSH and LH levels showed an increase statistically (p≤0.05) in comparison to the level of the control. Ricinodendron heudelotti seed extract effectively increased the reproductive hormones of the animals by increasing the serum Testosterone, FSH and LH levels, hence suggests its effectiveness in enhancement of the male reproductive function.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Augmentation Potency of Ethanol Seed Extract of Ricinodendron heudelotii on Some Male Reproductive Hormones in Wistar Albino Rats
    AU  - Tamuno-boma Odinga
    AU  - Ndidi Nwachoko
    AU  - Christine Umanu Gabriel-Brisibe
    Y1  - 2020/06/09
    PY  - 2020
    N1  - https://doi.org/10.11648/j.ijpc.20200602.11
    DO  - 10.11648/j.ijpc.20200602.11
    T2  - International Journal of Pharmacy and Chemistry
    JF  - International Journal of Pharmacy and Chemistry
    JO  - International Journal of Pharmacy and Chemistry
    SP  - 11
    EP  - 15
    PB  - Science Publishing Group
    SN  - 2575-5749
    UR  - https://doi.org/10.11648/j.ijpc.20200602.11
    AB  - The quest for the use of plants in the management of reproductive hormone dysfunction prompted this research. This study explored the effects of Ricinodendron heudelotti seed ethanol extract on some male reproductive hormones. Twenty five male albino rats were used. The animals were grouped into five and each group had five (5) albino rats. The extract was processed from the seeds of Ricinodendron heudelotti. Group A served as control, group B animals were administered with 300mg/kg.bw, while groups C, D and E animals were administered 450, 600 and 750 mg/kg.bw of the extract respectively for twenty one days. The animals were sacrificed and their blood samples were collected for the assay of testosterone, Follicle stimulating hormone (FSH) and Luteinizing hormone (LH). From the results obtained, the serum testosterone level of the experimental animals showed a concentration dependent increase in all the extract administered groups when compared with the value of the control group. FSH and LH levels showed an increase statistically (p≤0.05) in comparison to the level of the control. Ricinodendron heudelotti seed extract effectively increased the reproductive hormones of the animals by increasing the serum Testosterone, FSH and LH levels, hence suggests its effectiveness in enhancement of the male reproductive function.
    VL  - 6
    IS  - 2
    ER  - 

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Author Information
  • Department of Biochemistry, Faculty of Science, Rivers State University, Port Harcourt, Nigeria

  • Department of Biochemistry, Faculty of Science, Rivers State University, Port Harcourt, Nigeria

  • Department of Medical Biochemistry, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria

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