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GC–MS Analysis and Investigation of Bioactive Potential of Essential Oil from Citrus aurantium var. amara

Received: 31 May 2022     Accepted: 22 June 2022     Published: 30 June 2022
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Abstract

The need for efficient plant-based remedies is becoming acknowledged across the world as the incidence of infectious diseases rises. Essential oils have been actively studied in the research for plant-derived biomolecules that can substitute synthetic medications and, to some extent, eliminate or lessen their side effects. The goal of this study was to explore the presence of phytochemicals in neroli essential oil as well as its many therapeutic properties. We aimed to present a thorough viewpoint on researching essential oil extracted from the bloom of the bitter orange tree as a suitable replacement for synthetic counterparts. The various components present in the essential oil were identified using GC-MS analysis. The oil's antimicrobial properties were tested against a variety of fungal strains. The antioxidant potential was assessed using the DPPH (2,2-diphenyl-1-picrylhydrazy) reagent in a free radical scavenging experiment. The oil exhibited a variable degree of anti-microbial nature against the bacterial and fungal strains. Furthermore, the antimalarial and antituberculosis property was also evaluated against Plasmodium falciparum and Mycobacterium tuberculosis respectively. Finally, a study for determining the cytotoxicity activity of the oil was studied on the Chinese Hamster Ovary (CHO) cell line. The study's findings revealed that neroli essential oil has natural components that can be used to cure a variety of ailments.

Published in International Journal of Pharmacy and Chemistry (Volume 8, Issue 3)
DOI 10.11648/j.ijpc.20220803.11
Page(s) 24-34
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Anti-microbial, Anti-malarial, Anti-tuberculosis, Antioxidant, Cytotoxicity, DNA Barcoding, GC-MS

References
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Cite This Article
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    Vikas Jha, Aneesh Risbud, Sankalp Kasbe, Shreya Thube, Geetika Preman, et al. (2022). GC–MS Analysis and Investigation of Bioactive Potential of Essential Oil from Citrus aurantium var. amara. International Journal of Pharmacy and Chemistry, 8(3), 24-34. https://doi.org/10.11648/j.ijpc.20220803.11

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    ACS Style

    Vikas Jha; Aneesh Risbud; Sankalp Kasbe; Shreya Thube; Geetika Preman, et al. GC–MS Analysis and Investigation of Bioactive Potential of Essential Oil from Citrus aurantium var. amara. Int. J. Pharm. Chem. 2022, 8(3), 24-34. doi: 10.11648/j.ijpc.20220803.11

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    AMA Style

    Vikas Jha, Aneesh Risbud, Sankalp Kasbe, Shreya Thube, Geetika Preman, et al. GC–MS Analysis and Investigation of Bioactive Potential of Essential Oil from Citrus aurantium var. amara. Int J Pharm Chem. 2022;8(3):24-34. doi: 10.11648/j.ijpc.20220803.11

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  • @article{10.11648/j.ijpc.20220803.11,
      author = {Vikas Jha and Aneesh Risbud and Sankalp Kasbe and Shreya Thube and Geetika Preman and Sathi Maiti and Himadri Yadav and Farheen Khan and Fatimabi Shaikh and Tisha Jain},
      title = {GC–MS Analysis and Investigation of Bioactive Potential of Essential Oil from Citrus aurantium var. amara},
      journal = {International Journal of Pharmacy and Chemistry},
      volume = {8},
      number = {3},
      pages = {24-34},
      doi = {10.11648/j.ijpc.20220803.11},
      url = {https://doi.org/10.11648/j.ijpc.20220803.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20220803.11},
      abstract = {The need for efficient plant-based remedies is becoming acknowledged across the world as the incidence of infectious diseases rises. Essential oils have been actively studied in the research for plant-derived biomolecules that can substitute synthetic medications and, to some extent, eliminate or lessen their side effects. The goal of this study was to explore the presence of phytochemicals in neroli essential oil as well as its many therapeutic properties. We aimed to present a thorough viewpoint on researching essential oil extracted from the bloom of the bitter orange tree as a suitable replacement for synthetic counterparts. The various components present in the essential oil were identified using GC-MS analysis. The oil's antimicrobial properties were tested against a variety of fungal strains. The antioxidant potential was assessed using the DPPH (2,2-diphenyl-1-picrylhydrazy) reagent in a free radical scavenging experiment. The oil exhibited a variable degree of anti-microbial nature against the bacterial and fungal strains. Furthermore, the antimalarial and antituberculosis property was also evaluated against Plasmodium falciparum and Mycobacterium tuberculosis respectively. Finally, a study for determining the cytotoxicity activity of the oil was studied on the Chinese Hamster Ovary (CHO) cell line. The study's findings revealed that neroli essential oil has natural components that can be used to cure a variety of ailments.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - GC–MS Analysis and Investigation of Bioactive Potential of Essential Oil from Citrus aurantium var. amara
    AU  - Vikas Jha
    AU  - Aneesh Risbud
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    DO  - 10.11648/j.ijpc.20220803.11
    T2  - International Journal of Pharmacy and Chemistry
    JF  - International Journal of Pharmacy and Chemistry
    JO  - International Journal of Pharmacy and Chemistry
    SP  - 24
    EP  - 34
    PB  - Science Publishing Group
    SN  - 2575-5749
    UR  - https://doi.org/10.11648/j.ijpc.20220803.11
    AB  - The need for efficient plant-based remedies is becoming acknowledged across the world as the incidence of infectious diseases rises. Essential oils have been actively studied in the research for plant-derived biomolecules that can substitute synthetic medications and, to some extent, eliminate or lessen their side effects. The goal of this study was to explore the presence of phytochemicals in neroli essential oil as well as its many therapeutic properties. We aimed to present a thorough viewpoint on researching essential oil extracted from the bloom of the bitter orange tree as a suitable replacement for synthetic counterparts. The various components present in the essential oil were identified using GC-MS analysis. The oil's antimicrobial properties were tested against a variety of fungal strains. The antioxidant potential was assessed using the DPPH (2,2-diphenyl-1-picrylhydrazy) reagent in a free radical scavenging experiment. The oil exhibited a variable degree of anti-microbial nature against the bacterial and fungal strains. Furthermore, the antimalarial and antituberculosis property was also evaluated against Plasmodium falciparum and Mycobacterium tuberculosis respectively. Finally, a study for determining the cytotoxicity activity of the oil was studied on the Chinese Hamster Ovary (CHO) cell line. The study's findings revealed that neroli essential oil has natural components that can be used to cure a variety of ailments.
    VL  - 8
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Author Information
  • National Facility for Biopharmaceuticals, Guru Nanak Khalsa College, Mumbai, India

  • Department of Biomedical Engineering, The Pennsylvania State University, University Park, USA

  • Department of Five Years Integrated Course in Bioanalytical Sciences, Guru Nanak Khalsa College, Mumbai, India

  • Department of Five Years Integrated Course in Bioanalytical Sciences, Guru Nanak Khalsa College, Mumbai, India

  • Faculty of Nutrition and Biomedicine, Technische Universit?t München School of Life Sciences, Freising, Germany

  • Department of Five Years Integrated Course in Bioanalytical Sciences, Guru Nanak Khalsa College, Mumbai, India

  • National Facility for Biopharmaceuticals, Guru Nanak Khalsa College, Mumbai, India

  • Department of Five Years Integrated Course in Bioanalytical Sciences, Guru Nanak Khalsa College, Mumbai, India

  • Department of Five Years Integrated Course in Bioanalytical Sciences, Guru Nanak Khalsa College, Mumbai, India

  • Department of Five Years Integrated Course in Bioanalytical Sciences, Guru Nanak Khalsa College, Mumbai, India

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