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The Role of the Magnesium Valproate in Therapy for Patients with Treatment-Resistant Depression (TRD): Meat-Analysis Results of Chinese Data

Received: 10 October 2018     Accepted: 5 November 2018     Published: 3 December 2018
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Abstract

Background: Major depressive disorder is a prevalent and disabling illnessv, approximately 70% of patients do not remit after first-line antidepressant treatment, and about 20% develop to treatment-resistant depression(TRD). Treatment of TRD have been one of clinical problems. Adjunctive valprovate was a most sued ways for treatment of TRD. The magnesium valproate was common drug for both episode and bipolar disorder in China and also was used for TRD. To systematically evaluate the difference in efficacy of magnesium valproate and antidepressants for therapy of treatment-resistant depression(TRD) in China. Methods: Searches were applied to the following electronic databases in china: Chinese Biomedical Database (CBM), China National Knowledge Infrastructure (CNKI), WANFANG and Chinese Social Sciences Citation Index (VIP) databases. A total of 13 RCTs were included. A meta-analysis was performed of all the literatures germane to estimate the treatment-resistant depression patients treated with magnesium valproate combination with antidepressants and only antidepressants randomized controlled trials (RCTs) from 2010 to 2015. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated and the meta-analysis was conducted with Revman4.2 software. Results: A total of 13 RCTs were included for meta-analysis. The results of meta-analysis demonstrated by effective rate and depressive symptoms change between two groups of combination treatment with magnesium valproate and only antidepressant. The effective rate was higher in magnesium valproate combination with antidepressants group than that in antidepressants group(81/306, 35/298, Z=4.60, P=0.00001). The depressive scale was lower found in magnesium valproate combination with antidepressants group than that in antidepressants group after treatment (Z=16.20, P <0.00001). These results indicated that magnesium valproate combination with antidepressants maybe one better therapeutic way for TRD. Conclusion: The results indicate that magnesium valproate combination with antidepressants was better than antidepressants group in effective rate and improving depressive symptoms during treatment of patients with TRD. So these results may recommend to the patients with TRD though without the differences between groups.

Published in International Journal of Pharmacy and Chemistry (Volume 4, Issue 3)
DOI 10.11648/j.ijpc.20180403.11
Page(s) 23-30
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Magnesium Valproate, Antidepressants, TRD, Meta-analysis, Chinese Data

References
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Cite This Article
  • APA Style

    Chen Fengpei, Zhu Jianfeng, Gao Zhihan, Shen Yin, Jin Rui, et al. (2018). The Role of the Magnesium Valproate in Therapy for Patients with Treatment-Resistant Depression (TRD): Meat-Analysis Results of Chinese Data. International Journal of Pharmacy and Chemistry, 4(3), 23-30. https://doi.org/10.11648/j.ijpc.20180403.11

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    Chen Fengpei; Zhu Jianfeng; Gao Zhihan; Shen Yin; Jin Rui, et al. The Role of the Magnesium Valproate in Therapy for Patients with Treatment-Resistant Depression (TRD): Meat-Analysis Results of Chinese Data. Int. J. Pharm. Chem. 2018, 4(3), 23-30. doi: 10.11648/j.ijpc.20180403.11

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    AMA Style

    Chen Fengpei, Zhu Jianfeng, Gao Zhihan, Shen Yin, Jin Rui, et al. The Role of the Magnesium Valproate in Therapy for Patients with Treatment-Resistant Depression (TRD): Meat-Analysis Results of Chinese Data. Int J Pharm Chem. 2018;4(3):23-30. doi: 10.11648/j.ijpc.20180403.11

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  • @article{10.11648/j.ijpc.20180403.11,
      author = {Chen Fengpei and Zhu Jianfeng and Gao Zhihan and Shen Yin and Jin Rui and Ren Zhibin and Chen Zhenxin and Ma Yongchun and Jin Weidong},
      title = {The Role of the Magnesium Valproate in Therapy for Patients with Treatment-Resistant Depression (TRD): Meat-Analysis Results of Chinese Data},
      journal = {International Journal of Pharmacy and Chemistry},
      volume = {4},
      number = {3},
      pages = {23-30},
      doi = {10.11648/j.ijpc.20180403.11},
      url = {https://doi.org/10.11648/j.ijpc.20180403.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20180403.11},
      abstract = {Background: Major depressive disorder is a prevalent and disabling illnessv, approximately 70% of patients do not remit after first-line antidepressant treatment, and about 20% develop to treatment-resistant depression(TRD). Treatment of TRD have been one of clinical problems. Adjunctive valprovate was a most sued ways for treatment of TRD. The magnesium valproate was common drug for both episode and bipolar disorder in China and also was used for TRD. To systematically evaluate the difference in efficacy of magnesium valproate and antidepressants for therapy of treatment-resistant depression(TRD) in China. Methods: Searches were applied to the following electronic databases in china: Chinese Biomedical Database (CBM), China National Knowledge Infrastructure (CNKI), WANFANG and Chinese Social Sciences Citation Index (VIP) databases. A total of 13 RCTs were included. A meta-analysis was performed of all the literatures germane to estimate the treatment-resistant depression patients treated with magnesium valproate combination with antidepressants and only antidepressants randomized controlled trials (RCTs) from 2010 to 2015. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated and the meta-analysis was conducted with Revman4.2 software. Results: A total of 13 RCTs were included for meta-analysis. The results of meta-analysis demonstrated by effective rate and depressive symptoms change between two groups of combination treatment with magnesium valproate and only antidepressant. The effective rate was higher in magnesium valproate combination with antidepressants group than that in antidepressants group(81/306, 35/298, Z=4.60, P=0.00001). The depressive scale was lower found in magnesium valproate combination with antidepressants group than that in antidepressants group after treatment (Z=16.20, P <0.00001). These results indicated that magnesium valproate combination with antidepressants maybe one better therapeutic way for TRD. Conclusion: The results indicate that magnesium valproate combination with antidepressants was better than antidepressants group in effective rate and improving depressive symptoms during treatment of patients with TRD. So these results may recommend to the patients with TRD though without the differences between groups.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - The Role of the Magnesium Valproate in Therapy for Patients with Treatment-Resistant Depression (TRD): Meat-Analysis Results of Chinese Data
    AU  - Chen Fengpei
    AU  - Zhu Jianfeng
    AU  - Gao Zhihan
    AU  - Shen Yin
    AU  - Jin Rui
    AU  - Ren Zhibin
    AU  - Chen Zhenxin
    AU  - Ma Yongchun
    AU  - Jin Weidong
    Y1  - 2018/12/03
    PY  - 2018
    N1  - https://doi.org/10.11648/j.ijpc.20180403.11
    DO  - 10.11648/j.ijpc.20180403.11
    T2  - International Journal of Pharmacy and Chemistry
    JF  - International Journal of Pharmacy and Chemistry
    JO  - International Journal of Pharmacy and Chemistry
    SP  - 23
    EP  - 30
    PB  - Science Publishing Group
    SN  - 2575-5749
    UR  - https://doi.org/10.11648/j.ijpc.20180403.11
    AB  - Background: Major depressive disorder is a prevalent and disabling illnessv, approximately 70% of patients do not remit after first-line antidepressant treatment, and about 20% develop to treatment-resistant depression(TRD). Treatment of TRD have been one of clinical problems. Adjunctive valprovate was a most sued ways for treatment of TRD. The magnesium valproate was common drug for both episode and bipolar disorder in China and also was used for TRD. To systematically evaluate the difference in efficacy of magnesium valproate and antidepressants for therapy of treatment-resistant depression(TRD) in China. Methods: Searches were applied to the following electronic databases in china: Chinese Biomedical Database (CBM), China National Knowledge Infrastructure (CNKI), WANFANG and Chinese Social Sciences Citation Index (VIP) databases. A total of 13 RCTs were included. A meta-analysis was performed of all the literatures germane to estimate the treatment-resistant depression patients treated with magnesium valproate combination with antidepressants and only antidepressants randomized controlled trials (RCTs) from 2010 to 2015. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated and the meta-analysis was conducted with Revman4.2 software. Results: A total of 13 RCTs were included for meta-analysis. The results of meta-analysis demonstrated by effective rate and depressive symptoms change between two groups of combination treatment with magnesium valproate and only antidepressant. The effective rate was higher in magnesium valproate combination with antidepressants group than that in antidepressants group(81/306, 35/298, Z=4.60, P=0.00001). The depressive scale was lower found in magnesium valproate combination with antidepressants group than that in antidepressants group after treatment (Z=16.20, P <0.00001). These results indicated that magnesium valproate combination with antidepressants maybe one better therapeutic way for TRD. Conclusion: The results indicate that magnesium valproate combination with antidepressants was better than antidepressants group in effective rate and improving depressive symptoms during treatment of patients with TRD. So these results may recommend to the patients with TRD though without the differences between groups.
    VL  - 4
    IS  - 3
    ER  - 

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Author Information
  • The Graduate School, Zhejiang Chinese Medicine University, Hangzhou, China

  • The Graduate School, Zhejiang Chinese Medicine University, Hangzhou, China

  • The Graduate School, Zhejiang Chinese Medicine University, Hangzhou, China

  • Department of Psychiatry, Tongde Hospital Affiliated to Zhejiang Chinese Medicine University, Zhejiang Province Tongde Hospital, Zhejiang Province Mental Health Institute, Hangzhou, China

  • Department of Pharmacology, Tongde Hospital Affiliated to Zhejiang Chinese Medicine University, Zhejiang Province Tongde Hospital, Hangzhou, China

  • Department of Psychiatry, Tongde Hospital Affiliated to Zhejiang Chinese Medicine University, Zhejiang Province Tongde Hospital, Zhejiang Province Mental Health Institute, Hangzhou, China

  • Department of Psychiatry, Tongde Hospital Affiliated to Zhejiang Chinese Medicine University, Zhejiang Province Tongde Hospital, Zhejiang Province Mental Health Institute, Hangzhou, China

  • Department of Psychiatry, Tongde Hospital Affiliated to Zhejiang Chinese Medicine University, Zhejiang Province Tongde Hospital, Zhejiang Province Mental Health Institute, Hangzhou, China

  • The Graduate School, Zhejiang Chinese Medicine University, Hangzhou, China

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