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Current and Next Generation Vaccines Against Influenza

Received: 12 November 2018     Accepted: 28 November 2018     Published: 25 December 2018
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Abstract

Influenza is an infectious disease. In order to overcome various infectious diseases, many vaccines have been developed so far. Influenza vaccines have played an important role in prevention and control of influenza. However, current influenza vaccines are not perfect. Current influenza vaccines are produced by anticipating influenza viruses that may occur in annual epidemics or pandemics because influenza viruses have characteristic of antigen mutations. Furthermore, current subcutaneous or intramuscular inoculation of vaccine cannot sufficiently induce IgA that plays an important role in defending the entry of pathogens from the mucosa. In order to overcome the drawbacks of these current influenza vaccines, next generation vaccines are under investigation. One candidate is universal influenza vaccine using the antigens that are conserved among influenza virus strains. Another one is mucosal vaccine that can induce IgA on the mucosa of the upper respiratory tract. Here current and next generation influenza vaccines are described.

Published in International Journal of Pharmacy and Chemistry (Volume 4, Issue 4)
DOI 10.11648/j.ijpc.20180404.11
Page(s) 31-34
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Influenza, Hemagglutinin (HA), Universal Vaccine, Matrix Protein2 (M2), Mucosa

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Cite This Article
  • APA Style

    Kazuyoshi Kaminaka, Chikateru Nozaki. (2018). Current and Next Generation Vaccines Against Influenza. International Journal of Pharmacy and Chemistry, 4(4), 31-34. https://doi.org/10.11648/j.ijpc.20180404.11

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    ACS Style

    Kazuyoshi Kaminaka; Chikateru Nozaki. Current and Next Generation Vaccines Against Influenza. Int. J. Pharm. Chem. 2018, 4(4), 31-34. doi: 10.11648/j.ijpc.20180404.11

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    AMA Style

    Kazuyoshi Kaminaka, Chikateru Nozaki. Current and Next Generation Vaccines Against Influenza. Int J Pharm Chem. 2018;4(4):31-34. doi: 10.11648/j.ijpc.20180404.11

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  • @article{10.11648/j.ijpc.20180404.11,
      author = {Kazuyoshi Kaminaka and Chikateru Nozaki},
      title = {Current and Next Generation Vaccines Against Influenza},
      journal = {International Journal of Pharmacy and Chemistry},
      volume = {4},
      number = {4},
      pages = {31-34},
      doi = {10.11648/j.ijpc.20180404.11},
      url = {https://doi.org/10.11648/j.ijpc.20180404.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20180404.11},
      abstract = {Influenza is an infectious disease. In order to overcome various infectious diseases, many vaccines have been developed so far. Influenza vaccines have played an important role in prevention and control of influenza. However, current influenza vaccines are not perfect. Current influenza vaccines are produced by anticipating influenza viruses that may occur in annual epidemics or pandemics because influenza viruses have characteristic of antigen mutations. Furthermore, current subcutaneous or intramuscular inoculation of vaccine cannot sufficiently induce IgA that plays an important role in defending the entry of pathogens from the mucosa. In order to overcome the drawbacks of these current influenza vaccines, next generation vaccines are under investigation. One candidate is universal influenza vaccine using the antigens that are conserved among influenza virus strains. Another one is mucosal vaccine that can induce IgA on the mucosa of the upper respiratory tract. Here current and next generation influenza vaccines are described.},
     year = {2018}
    }
    

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    T1  - Current and Next Generation Vaccines Against Influenza
    AU  - Kazuyoshi Kaminaka
    AU  - Chikateru Nozaki
    Y1  - 2018/12/25
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    JF  - International Journal of Pharmacy and Chemistry
    JO  - International Journal of Pharmacy and Chemistry
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    AB  - Influenza is an infectious disease. In order to overcome various infectious diseases, many vaccines have been developed so far. Influenza vaccines have played an important role in prevention and control of influenza. However, current influenza vaccines are not perfect. Current influenza vaccines are produced by anticipating influenza viruses that may occur in annual epidemics or pandemics because influenza viruses have characteristic of antigen mutations. Furthermore, current subcutaneous or intramuscular inoculation of vaccine cannot sufficiently induce IgA that plays an important role in defending the entry of pathogens from the mucosa. In order to overcome the drawbacks of these current influenza vaccines, next generation vaccines are under investigation. One candidate is universal influenza vaccine using the antigens that are conserved among influenza virus strains. Another one is mucosal vaccine that can induce IgA on the mucosa of the upper respiratory tract. Here current and next generation influenza vaccines are described.
    VL  - 4
    IS  - 4
    ER  - 

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Author Information
  • Research Department, Kikuchi Research Center, KM Biologics Co., Ltd., Kumamoto, Japan

  • Department of Medical Technology, Kumamoto Health Science University, Kumamoto Japan

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